Contribution of neuronal subtypes to the neural representation of social interaction in control versus autistic mice

Position

Post-doc

Published Date

23 mars 2022

12 avr. 2022

Until filled

Application

poster

Application deadline

Keywords

Calcium imaging; awake behaving mice; social memory; quantitative analysis

The role

Behavioral studies have shown that mice can form social memories, i.e.,  to remember familiar conspecifics. Optogenetic studies have demonstrated  that assemblies of neurons in hippocampal ventral CA1 (vCA1) constitute  a primary site of social memory. However, vCA1 contains a diversity of  neuronal cell types with diverse functions and cellular targets, and the  identity(ies) of cell types involved in social interaction remains  unresolved. This postdoc project aims at determining which vCA1 cell  types encode social interaction and how this encoding is performed. We  will combine intersectional genetics and optogenetics with a  last-generation miniature microscope to record and manipulate the  calcium dynamics — as a proxy for neuronal activity — of different vCA1  cell types in awake mice during a social interaction task.  State-of-the-art computational methods will quantitatively correlate  mouse behavior and neural activity to disentangle and model encoding of  social interaction at both single cell and population levels.

The role

Behavioral studies have shown that mice can form social memories, i.e.,  to remember familiar conspecifics. Optogenetic studies have demonstrated  that assemblies of neurons in hippocampal ventral CA1 (vCA1) constitute  a primary site of social memory. However, vCA1 contains a diversity of  neuronal cell types with diverse functions and cellular targets, and the  identity(ies) of cell types involved in social interaction remains  unresolved. This postdoc project aims at determining which vCA1 cell  types encode social interaction and how this encoding is performed. We  will combine intersectional genetics and optogenetics with a  last-generation miniature microscope to record and manipulate the  calcium dynamics — as a proxy for neuronal activity — of different vCA1  cell types in awake mice during a social interaction task.  State-of-the-art computational methods will quantitatively correlate  mouse behavior and neural activity to disentangle and model encoding of  social interaction at both single cell and population levels.

Requirements

The candidate should be enthusiastic, creative and ambitious, have good communication skills and be eager to learn. A Ph.D. with experience in computer science is required. Affection for neuroscience is preferred. Note: exception can be made for candidates who have not studied computer science if the candidate can prove coding skills.

The offer

  • 2-year PostDoc position in the de Chevigny lab and the Guignard lab

  • Target start date: from Octover 2022

Application procedure

All applications must be done through the CENTURI portal at this address: https://centuri-livingsystems.org/application-form-pdp2022-04/


Questions can be addressed to Antoine de Chevigny or to Léo Guignard by email with the mention [Job-2022] in the title.


Antoine de Chevigny: antoine.de-chevigny@inserm.fr

Léo Guignard: leo.guignard@univ-amu.fr

Selection process and calendar

Call open for applications until April 13th


Interviews of shortlisted candidates by the evaluation committee: June 15 or 16.

The pre-selection process will be based on qualifications and expertise reflected on the candidates CV and motivation letter. It will be merit-based. All candidates will be informed whether they have been pre-selected or not.

Location

Léo Guignard and Antoine de Chevigny labs